What are the treatment recommendations for platinum
· Cannistra SA Matulonis UA Penson RT Hambleton J Dupont J Mackey H. Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer
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The Difference Between Relapsed Lymphoma and Refractory
· Relapsed Cancer "Relapsed" refers to a cancer that returns after a period of improvement. This applies whether the cancer was treated or untreated. Refractory Cancer "Refractory" refers to a cancer that proves resistant or does not respond to treatment. It doesn t matter whether the cancer is resistant to treatment immediately or whether it develops a resistance during treatment it is still called refractory.
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Platinum resistance/ refractoryOvarian Cancer Community
· Report. As to the platinum resistant v. refractory question I understand that if you achieve a complete response after a platinum based therapy but then recur within six months ou are considered "platinum-resistant". If you progress (or recur in a very short time) while on platinum-based therapy you are considered "platinum-refractory."
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Chemotherapy vs Hormonal Treatment in Platinum-resistant
· Chemotherapy vs Hormonal Treatment in Platinum-resistant Ovarian Cancer Resistant or Refractory to Platinum and Taxane. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
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Emerging Phase 3 Data in Relapsed/Refractory Metastatic
With its broad mechanism of action regorafenib can potentially suppress resistant clones not susceptible to a single drug with a single target. H O What data support the use of the newer agents RG The phase 3 RECOURSE (Study of TAS-102 in Patients With Metastatic Colorectal Cancer Refractory to Standard Chemotherapies) trial evaluated TAS-102
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Castration-Refractory Prostate Cancer New Therapies New
Resistance to androgen deprivation is an ominous milestone in the natural history of metastatic prostate cancer this disease state now referred to as castration-refractory prostate cancer (CRPC) is historically associated with a median survival of less than two years. Until recently only docetaxel (in combination with prednisone or estramustine) demonstrated a benefit in overall survival vs
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Management of Patients With Resistant or Refractory
23. O Hare T Walters DK Stoffregen EP et al In vitro activity of Bcr-Abl inhibitors AMN107 and BMS against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res 65 2005. 24. Deininger M Buchdunger E Druker BJ The development of imatinib as a therapeutic agent for chronic myeloid leukemia.
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What Is Relapsed vs. Refractory Myeloma The Myeloma
· Refractory Myeloma Dr. Damian Green MD of the Fred Hutchinson Cancer Center generally defines Refractory Myeloma as "disease that is progressing despite active treatment." The National Cancer Institute breaks it down even further to say that there are two main types of refractory
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Recurrent and Refractory Cancer Treatment Program
The Recurrent and Refractory Cancer Treatment Program is dedicated to working with patients whose cancers have recurred or are not responding to treatments. Our team specialists work with the Children s Oncology Group (COG) and other experts to offer patients
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Is there a difference between platinum resistant and
· Platinum refractory cancer grew while on platinum therapy. Platinum resistant recurrance within 6 months of platinum treatment. However I think they are more often than not used to
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Therapeutic Options in Docetaxel-Refractory Metastatic
· Almost all patients become refractory to ADT and the disease becomes metastatic castration-resistant prostate cancer (mCRPC) for which docetaxel is the standard-of-care. Until recently there were few FDA-approved options for patients who progressed following docetaxel treatment except for mitoxantrone which improves quality-of-life through
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Platinum resistance/ refractoryOvarian Cancer Community
· Report. As to the platinum resistant v. refractory question I understand that if you achieve a complete response after a platinum based therapy but then recur within six months ou are considered "platinum-resistant". If you progress (or recur in a very short time) while on platinum-based therapy you are considered "platinum-refractory."
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Avelumab in platinum-resistant/refractory ovarian cancer
· Women with PRROC ≤3 prior lines for platinum-sensitive disease and no prior therapy for platinum-resistant disease were randomized 1 1 1 to Ave (10 mg/kg Q2W) Ave PLD (40 mg/m 2 Q4W) or PLD. Pts were stratified by platinum status (refractory vs resistant) prior regimens (1 vs 2 or 3) and bulky disease (tumor ≥5 vs < 5 cm).
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Treatments for castrate-resistant prostate cancer
When cancer comes back or doesn t go away after hormonal therapy it is called castrate-resistant (hormone-refractory) prostate cancer. Your doctor will know that you have castrate-resistant prostate cancer if a blood test shows that your prostate-specific antigen (PSA) level
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Recurrent and Refractory Cancer Treatment Program
The Recurrent and Refractory Cancer Treatment Program is dedicated to working with patients whose cancers have recurred or are not responding to treatments. Our team specialists work with the Children s Oncology Group (COG) and other experts to offer patients
Get Price
Therapeutic Options in Docetaxel-Refractory Metastatic
· Almost all patients become refractory to ADT and the disease becomes metastatic castration-resistant prostate cancer (mCRPC) for which docetaxel is the standard-of-care. Until recently there were few FDA-approved options for patients who progressed following docetaxel treatment except for mitoxantrone which improves quality-of-life through
Get PriceEmerging Phase 3 Data in Relapsed/Refractory Metastatic
With its broad mechanism of action regorafenib can potentially suppress resistant clones not susceptible to a single drug with a single target. H O What data support the use of the newer agents RG The phase 3 RECOURSE (Study of TAS-102 in Patients With Metastatic Colorectal Cancer Refractory to Standard Chemotherapies) trial evaluated TAS-102
Get Price
Platinum resistance/ refractoryOvarian Cancer Community
· Report. As to the platinum resistant v. refractory question I understand that if you achieve a complete response after a platinum based therapy but then recur within six months ou are considered "platinum-resistant". If you progress (or recur in a very short time) while on platinum-based therapy you are considered "platinum-refractory."
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Definitions of Resistant and Refractory Cytomegalovirus
· In this article we aim to define refractory and/or resistant CMV infections after SOT or HCT to provide consistent criteria for future clinical trials and outcomes research. Clinical suspicion of drug-resistant CMV infections is usually based on suboptimal responses to antiviral agents leading to a treatment-refractory condition.
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Refractory Metastatic Colorectal Cancer Current
· Introduction. Colorectal cancer (CRC) is a major global health issue being the third most commonly diagnosed malignancy with an estimated global incidence of over 1.8 million in 2018 predicted to increase to 2.2 million in 2030. 1 2 CRC is the second commonest cause of global cancer mortality with 0.5 million deaths in 2018 predicted to increase to 1.1 million by 2030. 1 2 Twenty percent of
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Platinum-Resistant and Refractory Ovarian Cancer
· Patients with recurrent ovarian cancer who have a complete response to initial chemotherapy and a treatment-free interval <6 months demonstrate platinum resistance . 5 6 Refractory ovarian cancer is defined as stable or progressive disease during primary platinum-based therapy. 5 6 The difference between drug-sensitive and drug-resistant disease was initially described in relation to
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Treatments for castrate-resistant prostate cancer
When cancer comes back or doesn t go away after hormonal therapy it is called castrate-resistant (hormone-refractory) prostate cancer. Your doctor will know that you have castrate-resistant prostate cancer if a blood test shows that your prostate-specific antigen (PSA) level
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What is hormone-refractory prostate cancer
· In patients with serum testosterone castrate levels hormone-refractory prostate cancer is defined as 2-3 consecutive rises in prostate-specific antigen (PSA) levels obtained at intervals of
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Recurrent and Refractory Cancer Treatment Program
The Recurrent and Refractory Cancer Treatment Program is dedicated to working with patients whose cancers have recurred or are not responding to treatments. Our team specialists work with the Children s Oncology Group (COG) and other experts to offer patients
Get PriceMetastatic Castration-Resistant Prostate Cancer What s
· The term "castration resistant" refers to a cancer that is no longer responding to this type of therapy. According to the American Society of Clinical Oncology (ASCO) many men with prostate
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First-line Treatment for Metastatic Castrate-resistant
· Petrylak DP Tangen CM Hussain MH et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med. Oct 7 (15) . Kantoff PW Higano CS Shore ND et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. Jul 29 (5) .
Get PriceWhat is hormone-refractory prostate cancer
· In patients with serum testosterone castrate levels hormone-refractory prostate cancer is defined as 2-3 consecutive rises in prostate-specific antigen (PSA) levels obtained at intervals of
Get PriceWhat is Refractory Cancer and How Is It Treated Dana-Farber
· The word "refractory" in general use means stubborn or intractable and in medicine it is specifically applied to disease that does not respond to treatment. Refractory cancer refers to cancer that may be resistant at the beginning of treatment or becomes resistant during treatment.
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Hormone-Refractory Prostate Cancer or Castrate-Resistant
· The Hormone Refractory Prostate Cancer (HRPCa) Association was a volunteer organization of one hundred men with HRPCa their family members and their caregivers that existed from 1999 to 2016. Members were from all over the U.S. Canada and the
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